Epigenetic aspects of telocytes/cordocytes: jacks of all trades, masters of most
نویسندگان
چکیده
INTRODUCTION In a recent review (Smythies and Edelstein, 2013b) we described the structure and function of a new form of interstitial cell found in most mammalian organs, the telocyte/cordocyte (T/C) co-discovered and ascribed accordingly by teams led by Laurentiu Popescu (Popescu et al., 2005; “telocytes”) and Viorel Pais (Danaila and Pais, 2011; Pais et al., 2012, 2013a,b; “cordocytes”). The problem of nomenclature is further complicated by the persistent use of an old name—“interstitial cells of Cajal” or ICCs (e.g., Padhi et al., 2013; Tanahashi et al., 2013). T/Cs make synaptic contacts of various kinds (including puncta adhaerens and gap junctions) with a broad variety of cells and tissue (including blood vessels, nerve fibers, fibroblasts, muscle cells, immune cells, and glandular cells, as well as other T/Cs). The present consensus is that T/Cs are capable of forming an extensive intercellular information transmission and executive system that may utilize electric currents, small molecules, exosomes—and possibly electrical events within the cytoskeleton—to modulate homeostasis, stem cell activity, tissue repair, peristalsis, anticancer activity, and other complex functions in many organs. We herein present a more comprehensive hypothesis of the molecular and cellular bases of the function of T/Cs with a focus on mechanisms for tissue repair.
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2014